{"id":8669,"date":"2026-10-05T21:00:09","date_gmt":"2026-10-05T13:00:09","guid":{"rendered":"https:\/\/1ow.top\/index.php\/2026\/10\/05\/%e5%88%9a%e5%88%9a%ef%bc%8c%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96%e9%a2%81%e7%bb%99%e5%85%89%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%81\/"},"modified":"2026-10-05T21:00:09","modified_gmt":"2026-10-05T13:00:09","slug":"%e5%88%9a%e5%88%9a%ef%bc%8c%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96%e9%a2%81%e7%bb%99%e5%85%89%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%81","status":"publish","type":"post","link":"https:\/\/1ow.top\/index.php\/2026\/10\/05\/%e5%88%9a%e5%88%9a%ef%bc%8c%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96%e9%a2%81%e7%bb%99%e5%85%89%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%81\/","title":{"rendered":"\u521a\u521a\uff0c\u8bfa\u8d1d\u5c14\u5956\u9881\u7ed9\u5149\u9057\u4f20\u5b66\uff01"},"content":{"rendered":"
\"\u521a\u521a\uff0c\u8bfa\u8d1d\u5c14\u5956\u9881\u7ed9\u5149\u9057\u4f20\u5b66\uff01\"\/<\/div><\/figure>\n
\"\u521a\u521a\uff0c\u8bfa\u8d1d\u5c14\u5956\u9881\u7ed9\u5149\u9057\u4f20\u5b66\uff01\"\/<\/div><\/figure>\n
\"\u521a\u521a\uff0c\u8bfa\u8d1d\u5c14\u5956\u9881\u7ed9\u5149\u9057\u4f20\u5b66\uff01\"\/<\/div><\/figure>\n
\"\u521a\u521a\uff0c\u8bfa\u8d1d\u5c14\u5956\u9881\u7ed9\u5149\u9057\u4f20\u5b66\uff01\"\/<\/div><\/figure>\n

\u521a\u521a\uff0c2026\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u63ed\u6653\uff01<\/p>\n

Karl Deisseroth\u3001Peter Hegemann\u548cGeorg Nagel\u4e09\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u83b7\u5956\u3002<\/p>\n

\u8bfa\u8d1d\u5c14\u59d4\u5458\u4f1a\u7ed9\u51fa\u7684\u83b7\u5956\u7406\u7531\u662f\u2014\u2014\u8868\u5f70\u4ed6\u4eec\u5728\u5149\u63a7\u79bb\u5b50\u901a\u9053\u548c\u5149\u9057\u4f20\u5b66\u65b9\u9762\u7684\u53d1\u73b0\u3002<\/p>\n

\u4e09\u4f4d\u83b7\u5956\u8005\u5171\u540c\u5960\u5b9a\u7684\uff0c\u662f\u8fc7\u53bb20\u5e74\u795e\u7ecf\u79d1\u5b66\u6700\u91cd\u8981\u7684\u65b9\u6cd5\u5b66\u7a81\u7834\u4e4b\u4e00\uff1a\u5149\u9057\u4f20\u5b66\uff08Optogenetics\uff09\u3002<\/p>\n

\u5176\u6700\u6838\u5fc3\u7684\u7a81\u7834\uff0c\u662f\u8ba9\u79d1\u5b66\u5bb6\u80fd\u591f\u501f\u52a9\u5149\uff0c\u5728\u6beb\u79d2\u7ea7\u65f6\u95f4\u5c3a\u5ea6\u4e0a\u7cbe\u51c6\u6fc0\u6d3b\u6216\u6291\u5236\u7279\u5b9a\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u3002<\/p>\n

\u8fc7\u53bb\uff0c\u7814\u7a76\u4eba\u5458\u5f80\u5f80\u53ea\u80fd\u89c2\u5bdf\u5230\uff0c\u67d0\u7247\u8111\u533a\u3001\u67d0\u4e00\u7fa4\u795e\u7ecf\u5143\uff0c\u4f1a\u5728\u8bb0\u5fc6\u5f62\u6210\u3001\u60c5\u7eea\u53d8\u5316\u3001\u8fd0\u52a8\u63a7\u5236\u6216\u67d0\u79cd\u884c\u4e3a\u51fa\u73b0\u65f6\u540c\u6b65\u6d3b\u8dc3\u3002<\/p>\n

\u5149\u9057\u4f20\u5b66\u6539\u53d8\u4e86\u8fd9\u4e00\u70b9\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u4e3b\u52a8\u64cd\u63a7\u7279\u5b9a\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\uff0c\u518d\u89c2\u5bdf\u884c\u4e3a\u662f\u5426\u968f\u4e4b\u53d1\u751f\u3001\u51cf\u5f31\u6216\u6d88\u5931\uff0c\u7531\u6b64\u628a\u5f88\u591a\u95ee\u9898\u4ece\u76f8\u5173\u6027\u89c2\u5bdf\u63a8\u8fdb\u5230\u56e0\u679c\u5173\u7cfb\u9a8c\u8bc1\u3002<\/p>\n

\u8fd9\u5957\u65b9\u6cd5\u540e\u6765\u8fc5\u901f\u6210\u4e3a\u7814\u7a76\u795e\u7ecf\u56de\u8def\u7684\u91cd\u8981\u5de5\u5177\uff0c\u5e76\u88ab\u5e7f\u6cdb\u7528\u4e8e\u8bb0\u5fc6\u3001\u5956\u8d4f\u3001\u6210\u763e\u3001\u8fd0\u52a8\u63a7\u5236\uff0c\u4ee5\u53ca\u591a\u7c7b\u795e\u7ecf\u548c\u7cbe\u795e\u75be\u75c5\u673a\u5236\u7814\u7a76\u3002<\/p>\n

\u800c\u8fd9\u573a\u795e\u7ecf\u79d1\u5b66\u5de5\u5177\u9769\u547d\uff0c\u8d77\u70b9\u5176\u5b9e\u6765\u81ea\u4e00\u79cd\u4f1a\u8ffd\u7740\u5149\u6e38\u52a8\u7684\u5355\u7ec6\u80de\u7eff\u85fb\u3002<\/p>\n

\u5149\u9057\u4f20\u5b66\u8fd9\u6761\u6280\u672f\u8def\u7ebf\uff0c\u8d77\u70b9\u5176\u5b9e\u5f88\u610f\u5916\u2014\u2014\u7eff\u85fb\u3002<\/p>\n

\u6709\u4e9b\u5355\u7ec6\u80de\u7eff\u85fb\u4f1a\u6839\u636e\u5149\u7167\u6539\u53d8\u6e38\u52a8\u65b9\u5411\u3002\u4e3a\u4e86\u5b8c\u6210\u8fd9\u4ef6\u4e8b\uff0c\u5b83\u4eec\u4f53\u5185\u9700\u8981\u4e00\u5957\u80fd\u628a\u201c\u5149\u201d\u5feb\u901f\u8f6c\u6210\u201c\u7535\u4fe1\u53f7\u201d\u7684\u673a\u5236\u3002<\/p>\n

\u5b83\u672c\u8d28\u4e0a\u662f\u4e00\u79cd\u5149\u63a7\u79bb\u5b50\u901a\u9053\uff0c\u5149\u7167\u4e0a\u53bb\uff0c\u901a\u9053\u6253\u5f00\uff0c\u79bb\u5b50\u7a7f\u8fc7\u7ec6\u80de\u819c\uff0c\u7ec6\u80de\u819c\u7535\u4f4d\u968f\u4e4b\u53d1\u751f\u53d8\u5316\u3002<\/p>\n

\u8fd9\u4ef6\u4e8b\u653e\u5230\u795e\u7ecf\u5143\u4e0a\uff0c\u6709\u610f\u601d\u7684\u4e00\u70b9\u662f\uff0c\u795e\u7ecf\u5143\u4f20\u9012\u4fe1\u606f\uff0c\u672c\u6765\u5c31\u4f9d\u8d56\u79bb\u5b50\u6d41\u548c\u819c\u7535\u4f4d\u53d8\u5316\u3002<\/p>\n

\u6240\u4ee5\u53ea\u8981\u628a\u8fd9\u79cd\u300c\u89c1\u5149\u5c31\u5f00\u300d\u7684\u79bb\u5b50\u901a\u9053\u88c5\u8fdb\u795e\u7ecf\u5143\uff0c\u7406\u8bba\u4e0a\u5c31\u53ef\u4ee5\u76f4\u63a5\u7528\u5149\u63a7\u5236\u795e\u7ecf\u5143\u4ec0\u4e48\u65f6\u5019\u653e\u7535\u3002<\/p>\n

Peter Hegemann\u548cGeorg Nagel\u505a\u7684\uff0c\u5c31\u662f\u628a\u8fd9\u6247\u95e8\u771f\u6b63\u63a8\u5f00\u3002<\/p>\n

Hegemann\u957f\u671f\u7814\u7a76\u5355\u7ec6\u80de\u7eff\u85fbChlamydomonas reinhardtii\u5982\u4f55\u611f\u77e5\u5149\u3002<\/p>\n

\u8fd9\u79cd\u7eff\u85fb\u6ca1\u6709\u773c\u775b\uff0c\u5374\u80fd\u8ffd\u7740\u5149\u6e38\u52a8\uff0c\u4e8e\u662fHegemann\u5f88\u65e9\u5c31\u610f\u8bc6\u5230\uff0c\u8fd9\u91cc\u9762\u53ef\u80fd\u85cf\u7740\u4e00\u79cd\u80fd\u628a\u5149\u523a\u6fc0\u76f4\u63a5\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\u7684\u86cb\u767d\u3002<\/p>\n

2002\u5e74\uff0cHegemann\u3001Nagel\u53ca\u5176\u5408\u4f5c\u8005\u9274\u5b9a\u51fa\u4e86\u7b2c\u4e00\u79cdChannelrhodopsin\u3002<\/p>\n

2003\u5e74\uff0c\u4ed6\u4eec\u8fdb\u4e00\u6b65\u8868\u5f81\u4e86Channelrhodopsin-2\uff0c\u4e5f\u5c31\u662fChR2\uff0c\u786e\u8ba4\u5b83\u662f\u4e00\u79cd\u53ef\u4ee5\u88ab\u5149\u76f4\u63a5\u6253\u5f00\u7684\u9633\u79bb\u5b50\u901a\u9053\u3002<\/p>\n

\u81f3\u6b64\uff0c\u4e00\u4e2a\u5929\u7136\u5b58\u5728\u4e8e\u7eff\u85fb\u91cc\u7684\u201c\u5149\u5f00\u5173\u201d\u88ab\u627e\u5230\u4e86\u3002<\/p>\n

\u63a5\u4e0b\u6765\uff0cKarl Deisseroth\u628a\u5b83\u771f\u6b63\u53d8\u6210\u4e86\u795e\u7ecf\u79d1\u5b66\u5de5\u5177\u3002<\/p>\n

2005\u5e74\uff0cDeisseroth\u56e2\u961f\u5c06ChR2\u5f15\u5165\u54fa\u4e73\u52a8\u7269\u795e\u7ecf\u5143\uff0c\u7ed3\u679c\u53d1\u73b0\u53ea\u9700\u8981\u84dd\u5149\u7167\u5c04\uff0c\u5c31\u80fd\u591f\u4ee5\u6beb\u79d2\u7ea7\u7cbe\u5ea6\u8bf1\u5bfc\u795e\u7ecf\u5143\u4ea7\u751f\u52a8\u4f5c\u7535\u4f4d\u3002<\/p>\n

\u5230\u8fd9\u91cc\uff0c\u5149\u9057\u4f20\u5b66\u771f\u6b63\u6210\u5f62\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53ef\u4ee5\u501f\u52a9\u9057\u4f20\u5b66\u65b9\u6cd5\uff0c\u53ea\u8ba9\u7279\u5b9a\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u8868\u8fbe\u8fd9\u79cd\u5149\u654f\u86cb\u767d\u3002<\/p>\n

\u4e8e\u662f\u8fc7\u53bb\u5f88\u96be\u505a\u7684\u4e00\u4ef6\u4e8b\uff0c\u7a81\u7136\u53d8\u5f97\u53ef\u64cd\u4f5c\u4e86\u2014\u2014<\/p>\n

\u9009\u4e2d\u4e00\u7c7b\u795e\u7ecf\u5143\uff0c\u7ed9\u5b83\u4eec\u88c5\u4e0a\u201c\u5149\u5f00\u5173\u201d\uff0c\u518d\u7528\u5149\u7cbe\u51c6\u63a7\u5236\u5b83\u4eec\u4ec0\u4e48\u65f6\u5019\u542f\u52a8\u3001\u4ec0\u4e48\u65f6\u5019\u6c89\u9ed8\u3002<\/p>\n

\u5149\u9057\u4f20\u5b66\u6700\u91cd\u8981\u7684\u5730\u65b9\uff0c\u5728\u4e8e\u5b83\u89e3\u51b3\u4e86\u795e\u7ecf\u79d1\u5b66\u4e00\u4e2a\u957f\u671f\u96be\u9898\uff0c\u90a3\u5c31\u662f\u600e\u4e48\u4ece\u201c\u770b\u89c1\u5927\u8111\u6d3b\u52a8\u201d\uff0c\u8d70\u5230\u201c\u9a8c\u8bc1\u5230\u5e95\u662f\u8c01\u5728\u63a7\u5236\u884c\u4e3a\u201d\u3002<\/p>\n

\u540e\u6765\uff0c\u8fd9\u5957\u65b9\u6cd5\u88ab\u5e7f\u6cdb\u7528\u4e8e\u7814\u7a76\u8bb0\u5fc6\u3001\u7761\u7720\u3001\u5956\u8d4f\u3001\u6210\u763e\u3001\u8fd0\u52a8\u3001\u7126\u8651\u3001\u6291\u90c1\u3001\u793e\u4ea4\u884c\u4e3a\uff0c\u4ee5\u53ca\u5404\u79cd\u795e\u7ecf\u548c\u7cbe\u795e\u75be\u75c5\u76f8\u5173\u8111\u56de\u8def\u3002<\/p>\n

\u5b83\u6700\u5927\u7684\u4f18\u52bf\u4e5f\u5f88\u660e\u786e\uff0c\u90a3\u5c31\u662f\u65e2\u80fd\u9501\u5b9a\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\uff0c\u53c8\u6709\u5f88\u9ad8\u7684\u7a7a\u95f4\u7cbe\u5ea6\uff0c\u540c\u65f6\u8fd8\u80fd\u505a\u5230\u6beb\u79d2\u7ea7\u65f6\u95f4\u63a7\u5236\u3002<\/p>\n

\u8fc7\u53bb20\u5e74\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u53c8\u4e0d\u65ad\u6539\u9020Channelrhodopsin\u3002<\/p>\n

\u6709\u7684\u54cd\u5e94\u66f4\u5feb\uff0c\u6709\u7684\u53ef\u4ee5\u88ab\u4e0d\u540c\u989c\u8272\u7684\u5149\u6fc0\u6d3b\uff0c\u6709\u7684\u8d1f\u8d23\u201c\u6253\u5f00\u201d\u795e\u7ecf\u5143\uff0c\u6709\u7684\u8d1f\u8d23\u201c\u5173\u6389\u201d\u795e\u7ecf\u5143\u3002<\/p>\n

\u6240\u4ee5\u4eca\u5e74\u8bfa\u5956\u5b98\u65b9\u8868\u8ff0\u91cc\uff0c\u7279\u610f\u628a\u4e24\u90e8\u5206\u5e76\u5217\u5199\u51fa\u6765\uff1a\u201clight-gated ion channels\u201d \u548c \u201coptogenetics\u201d\u3002<\/p>\n

\u524d\u4e00\u90e8\u5206\u5bf9\u5e94\u7684\u662fHegemann\u3001Nagel\u7b49\u4eba\u5bf9\u5149\u63a7\u79bb\u5b50\u901a\u9053\u7684\u53d1\u73b0\u548c\u673a\u5236\u7814\u7a76\u3002<\/p>\n

\u540e\u4e00\u90e8\u5206\u5219\u5bf9\u5e94Deisseroth\u7b49\u4eba\u628a\u8fd9\u4e9b\u5206\u5b50\u5de5\u5177\u771f\u6b63\u5e26\u8fdb\u795e\u7ecf\u7cfb\u7edf\uff0c\u5e76\u53d1\u5c55\u6210\u53ef\u4ee5\u64cd\u7eb5\u795e\u7ecf\u56de\u8def\u7684\u6280\u672f\u4f53\u7cfb\u3002<\/p>\n

\u4e09\u4e2a\u4eba\u7684\u8d21\u732e\u4e32\u8d77\u6765\uff0c\u5176\u5b9e\u5c31\u662f\u4e00\u6761\u5f88\u5b8c\u6574\u7684\u8def\u7ebf\u2014\u2014<\/p>\n

\u5148\u627e\u5230\u7eff\u85fb\u91cc\u7684\u201c\u5149\u5f00\u5173\u201d\uff0c\u518d\u628a\u5b83\u88c5\u8fdb\u795e\u7ecf\u5143\uff0c\u6700\u540e\u8ba9\u79d1\u5b66\u5bb6\u7b2c\u4e00\u6b21\u53ef\u4ee5\u7528\u5149\u53bb\u7cbe\u51c6\u63a7\u5236\u5927\u8111\u91cc\u7684\u7279\u5b9a\u7ec6\u80de\u3002<\/p>\n

\u5361\u5c14\u00b7\u4e9a\u5386\u5c71\u5927\u00b7\u4ee3\u585e\u5c14\u7f57\u601d\uff08Karl Alexander Deisseroth\uff0c1971\u5e7411\u670818\u65e5\u2014\uff09\uff0c\u7f8e\u56fd\u795e\u7ecf\u79d1\u5b66\u5bb6\u3001\u7cbe\u795e\u79d1\u533b\u751f\u548c\u751f\u7269\u5de5\u7a0b\u5b66\u5bb6\uff0c\u73b0\u4efb\u65af\u5766\u798f\u5927\u5b66\u751f\u7269\u5de5\u7a0b\u53ca\u7cbe\u795e\u75c5\u5b66\u4e0e\u884c\u4e3a\u79d1\u5b66\u6559\u6388\u3001\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u3002<\/p>\n

\u4ed6\u7684\u7ecf\u5386\u5f88\u5178\u578b\u5730\u6a2a\u8de8\u4e86\u533b\u5b66\u3001\u795e\u7ecf\u79d1\u5b66\u548c\u5de5\u7a0b\u5b66\u3002<\/p>\n

1992\u5e74\uff0cDeisseroth\u4ece\u54c8\u4f5b\u5927\u5b66\u751f\u5316\u79d1\u5b66\u4e13\u4e1a\u6bd5\u4e1a\uff0c\u968f\u540e\u8fdb\u5165\u65af\u5766\u798fMD-PhD\u9879\u76ee\uff0c1998\u5e74\u83b7\u5f97\u795e\u7ecf\u79d1\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c2000\u5e74\u83b7\u5f97\u533b\u5b66\u535a\u58eb\u5b66\u4f4d\u3002<\/p>\n

\u771f\u6b63\u8ba9\u4ed6\u7ad9\u5230\u5149\u9057\u4f20\u5b66\u4e2d\u5fc3\u4f4d\u7f6e\u7684\uff0c\u662f2005\u5e74\u7684\u90a3\u9879\u5de5\u4f5c\u3002<\/p>\n

\u5f53\u65f6Deisseroth\u4e0eEdward Boyden\u3001\u5f20\u950b\u7b49\u4eba\u5c06Channelrhodopsin-2\uff0c\u4e5f\u5c31\u662fChR2\uff0c\u5f15\u5165\u54fa\u4e73\u52a8\u7269\u795e\u7ecf\u5143\uff0c\u968f\u540e\u53d1\u73b0\u2014\u2014<\/p>\n

\u53ea\u9700\u8981\u84dd\u5149\u7167\u5c04\uff0c\u5c31\u80fd\u4ee5\u6beb\u79d2\u7ea7\u7cbe\u5ea6\u63a7\u5236\u795e\u7ecf\u5143\u4ea7\u751f\u52a8\u4f5c\u7535\u4f4d\u3002<\/p>\n

\u8fd9\u4e00\u6b65\u76f4\u63a5\u628a\u6b64\u524d\u5b58\u5728\u4e8e\u5fae\u751f\u7269\u91cc\u7684\u201c\u5149\u63a7\u79bb\u5b50\u901a\u9053\u201d\uff0c\u53d8\u6210\u4e86\u53ef\u4ee5\u62ff\u6765\u64cd\u7eb5\u795e\u7ecf\u7cfb\u7edf\u7684\u5de5\u5177\u3002<\/p>\n

\u6b64\u540e\uff0cDeisseroth\u56e2\u961f\u7ee7\u7eed\u63a8\u52a8\u5149\u9057\u4f20\u5b66\u53d1\u5c55\uff0c\u5e76\u5f00\u53d1\u51faCLARITY\u7b49\u7ec4\u7ec7\u900f\u660e\u5316\u548c\u6210\u50cf\u6280\u672f\u3002<\/p>\n

\u6240\u4ee5\u4ed6\u7684\u8d21\u732e\u5f88\u660e\u786e\uff1a\u628a\u5149\u63a7\u79bb\u5b50\u901a\u9053\u771f\u6b63\u5e26\u8fdb\u795e\u7ecf\u79d1\u5b66\uff0c\u8ba9\u201c\u7528\u5149\u63a7\u5236\u795e\u7ecf\u5143\u201d\u6210\u4e3a\u4e00\u5957\u53ef\u4ee5\u5927\u89c4\u6a21\u4f7f\u7528\u7684\u65b9\u6cd5\u3002<\/p>\n

\u5f7c\u5f97\u00b7\u9ed1\u683c\u66fc\uff08Peter Hegemann\uff0c1954\u5e7412\u670811\u65e5\u2014\uff09\uff0c\u5fb7\u56fd\u751f\u7269\u7269\u7406\u5b66\u5bb6\uff0c\u73b0\u4efb\u67cf\u6797\u6d2a\u5821\u5927\u5b66\u5b9e\u9a8c\u751f\u7269\u7269\u7406\u5b66\u6559\u6388\u3001\u795e\u7ecf\u79d1\u5b66Hertie\u8bb2\u5e2d\u6559\u6388\u3002<\/p>\n

\u76f8\u6bd4Deisseroth\uff0cHegemann\u8d70\u7684\u662f\u4e00\u6761\u66f4\u7eaf\u7cb9\u7684\u57fa\u7840\u7814\u7a76\u8def\u7ebf\u3002<\/p>\n

\u4ed6\u51fa\u751f\u4e8e\u5fb7\u56fd\u660e\u65af\u7279\uff0c\u5148\u540e\u5728\u660e\u65af\u7279\u5927\u5b66\u548c\u6155\u5c3c\u9ed1\u5927\u5b66\u5b66\u4e60\u5316\u5b66\u4e0e\u751f\u7269\u5316\u5b66\uff0c1984\u5e74\u5728\u9a6c\u514b\u65af\u00b7\u666e\u6717\u514b\u751f\u7269\u5316\u5b66\u7814\u7a76\u6240\u5b8c\u6210\u535a\u58eb\u7814\u7a76\u3002<\/p>\n

1993\u5e74\u8d77\uff0c\u4ed6\u62c5\u4efb\u96f7\u6839\u65af\u5821\u5927\u5b66\u6559\u6388\uff0c\u968f\u540e\u8f6c\u5165\u67cf\u6797\u6d2a\u5821\u5927\u5b66\u3002<\/p>\n

\u51e0\u5341\u5e74\u6765\uff0cHegemann\u4e00\u76f4\u5728\u7814\u7a76\u4e00\u4e2a\u770b\u8d77\u6765\u975e\u5e38\u57fa\u7840\u7684\u95ee\u9898\uff1a\u5355\u7ec6\u80de\u5fae\u85fb\u7a76\u7adf\u600e\u4e48\u611f\u77e5\u5149\uff1f<\/p>\n

\u8fd9\u79cd\u7814\u7a76\u540e\u6765\u76f4\u63a5\u901a\u5411\u4e86Channelrhodopsin\u3002<\/p>\n

\u4ed6\u4e0eGeorg Nagel\u7b49\u4eba\u53d1\u73b0\u5e76\u8868\u5f81\u4e86\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\uff0c\u8bc1\u660e\u8fd9\u79cd\u86cb\u767d\u80fd\u591f\u628a\u611f\u53d7\u5149\u7ebf\u548c\u63a7\u5236\u79bb\u5b50\u6d41\u4e24\u4ef6\u4e8b\u96c6\u6210\u5728\u540c\u4e00\u4e2a\u5206\u5b50\u91cc\u3002<\/p>\n

\u5bf9\u5149\u9057\u4f20\u5b66\u6765\u8bf4\uff0c\u8fd9\u4e00\u6b65\u76f8\u5f53\u4e8e\u627e\u5230\u4e86\u6700\u6838\u5fc3\u7684\u201c\u96f6\u4ef6\u201d\u3002<\/p>\n

\u6ca1\u6709\u8fd9\u4e2a\u5929\u7136\u5b58\u5728\u7684\u5149\u63a7\u79bb\u5b50\u901a\u9053\uff0c\u540e\u9762\u201c\u7528\u5149\u63a7\u5236\u795e\u7ecf\u5143\u201d\u8fd9\u5957\u6280\u672f\u4e5f\u65e0\u4ece\u8c08\u8d77\u3002<\/p>\n

Georg Nagel\uff0c1953\u5e74\u51fa\u751f\uff0c\u5fb7\u56fd\u751f\u7269\u7269\u7406\u5b66\u5bb6\uff0c\u73b0\u4efb\u7ef4\u5c14\u8328\u5821\u5927\u5b66\u6559\u6388\uff0c\u957f\u671f\u7814\u7a76\u5fae\u751f\u7269\u5149\u611f\u53d7\u5668\u3001\u819c\u86cb\u767d\u4ee5\u53ca\u5149\u9057\u4f20\u5b66\u5de5\u5177\u3002<\/p>\n

Nagel\u51fa\u751f\u4e8e\u5fb7\u56fd\u9b4f\u6069\u52a0\u6ed5\uff0c\u66fe\u5728\u5eb7\u65af\u5766\u8328\u5927\u5b66\u5b66\u4e60\u751f\u7269\u5b66\u548c\u751f\u7269\u7269\u7406\u5b66\uff0c1988\u5e74\u83b7\u5f97\u6cd5\u5170\u514b\u798f\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\u3002<\/p>\n

\u4e4b\u540e\uff0c\u4ed6\u5148\u540e\u5728\u8036\u9c81\u5927\u5b66\u548c\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\uff0c\u5e76\u957f\u671f\u5728\u9a6c\u514b\u65af\u00b7\u666e\u6717\u514b\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u9886\u5bfc\u7814\u7a76\u7ec4\u3002<\/p>\n

\u4ed6\u6700\u5173\u952e\u7684\u8d21\u732e\uff0c\u96c6\u4e2d\u5728Channelrhodopsin\u771f\u6b63\u88ab\u201c\u9489\u6b7b\u8eab\u4efd\u201d\u7684\u90a3\u51e0\u5e74\u3002<\/p>\n

2002\u5e74\u548c2003\u5e74\uff0cNagel\u4e0eHegemann\u7b49\u4eba\u5148\u540e\u9274\u5b9a\u5e76\u8868\u5f81Channelrhodopsin-1\u548cChannelrhodopsin-2\u3002<\/p>\n

\u5176\u4e2dChR2\u5c24\u5176\u5173\u952e\u3002<\/p>\n

\u4ed6\u4eec\u8bc1\u660e\uff0cChR2\u672c\u8eab\u5c31\u662f\u4e00\u79cd\u53ef\u4ee5\u88ab\u5149\u76f4\u63a5\u6fc0\u6d3b\u7684\u9633\u79bb\u5b50\u901a\u9053\uff0c\u800c\u4e14\u628a\u5b83\u653e\u8fdb\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u540e\uff0c\u5149\u7167\u5c31\u80fd\u8ba9\u7ec6\u80de\u819c\u53d1\u751f\u53bb\u6781\u5316\u3002<\/p>\n

\u8fd9\u4e00\u6b65\u51e0\u4e4e\u76f4\u63a5\u7ed9\u51fa\u4e86\u540e\u6765\u7684\u6280\u672f\u8def\u7ebf\uff1a\u65e2\u7136\u5149\u53ef\u4ee5\u901a\u8fc7ChR2\u6539\u53d8\u7ec6\u80de\u819c\u7535\u6d3b\u52a8\uff0c\u90a3\u628a\u5b83\u88c5\u8fdb\u795e\u7ecf\u5143\uff0c\u5c31\u6709\u673a\u4f1a\u76f4\u63a5\u63a7\u5236\u795e\u7ecf\u5143\u653e\u7535\u3002<\/p>\n

Hegemann\u548cNagel\u627e\u5230\u4e86\u5e76\u641e\u6e05\u695a\u201c\u5149\u5f00\u5173\u201d\u672c\u8eab\uff0cDeisseroth\u5219\u628a\u8fd9\u4e2a\u201c\u5149\u5f00\u5173\u201d\u771f\u6b63\u88c5\u8fdb\u795e\u7ecf\u5143\uff0c\u53d1\u5c55\u6210\u5149\u9057\u4f20\u5b66\u3002<\/p>\n

\u8fd9\u4e00\u524d\u4e00\u540e\uff0c\u624d\u6709\u4e86\u4eca\u5929\u6574\u5957\u7528\u5149\u7814\u7a76\u5927\u8111\u7684\u6280\u672f\u4f53\u7cfb\u3002<\/p>\n

\u53c2\u8003\u94fe\u63a5\uff1a[1]https:\/\/med.stanford.edu\/profiles\/karl-deisseroth[2]https:\/\/brainprize.org\/winners\/optogenetics-2013\/peter-hegemann[3]https:\/\/www.biologie.hu-berlin.de\/de\/gruppenseiten\/expbp\/groupmembers\/prof.-hegemann-peter<\/p>\n

\n

\u7248\u6743\u58f0\u660e\uff1a<\/strong><\/p>\n

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\u8f6c\u8f7d\u4ec5\u4e3a\u4e2a\u4eba\u5b66\u4e60\u4e0e\u4ea4\u6d41\u76ee\u7684\uff0c\u4e0d\u5bf9\u6587\u7ae0\u89c2\u70b9\u8d1f\u8d23\uff0c\u4ea6\u4e0d\u7528\u4e8e\u4efb\u4f55\u5546\u4e1a\u7528\u9014\u3002<\/p>\n

\u5982\u6d89\u53ca\u7248\u6743\u95ee\u9898\uff0c\u8bf7\u8054\u7cfb\u672c\u4eba\u5220\u9664\u3002<\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"

\u521a\u521a\uff0c2026\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u63ed\u6653\uff01<\/p>\n

Karl Deisseroth\u3001Peter Hegemann\u548cGeorg Nagel\u4e09\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u83b7\u5956\u3002<\/p>\n

\u8bfa\u8d1d\u5c14\u59d4\u5458\u4f1a\u7ed9\u51fa\u7684\u83b7\u5956\u7406\u7531\u662f\u2014\u2014\u8868\u5f70\u4ed6\u4eec\u5728\u5149\u63a7\u79bb\u5b50\u901a\u9053\u548c\u5149\u9057\u4f20\u5b66\u65b9\u9762\u7684\u53d1\u73b0\u3002<\/p>\n

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