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\u4ee5\u6291\u90c1\u75c7\u76f8\u5173\u86cb\u767d\u4e3a\u4f8b\uff0c\u7814\u7a76\u8005\u4ece\u7b5b\u9009\u51fa\u768478\u4e2a\u5206\u5b50\u91cc\uff0c\u627e\u52308\u4e2a\u80fd\u6fc0\u6d3b\u8fd9\u4e2a\u86cb\u767d\u7684\u201c\u6fc0\u52a8\u5242\u201d\u3002<\/p>\n

\u5176\u4e2d\u6700\u597d\u7684\u4e00\u4e2a\u5206\u5b50\uff0c\u548c\u86cb\u767d\u7684\u7ed3\u5408\u80fd\u529b\u8fbe\u523021nM\uff08\u6570\u503c\u8d8a\u5c0f\u7ed3\u5408\u8d8a\u5f3a\uff0c100nM\u4ee5\u4e0b\u5c31\u662f\u4f18\u79c0\u6c34\u5e73\uff09\uff0c\u5728\u7ec6\u80de\u7cfb\u4e2d\u4e5f\u6709\u663e\u8457\u6d3b\u6027\u3002<\/p>\n

\u56e2\u961f\u8fd8\u4e0e\u6e05\u534e\u5927\u5b66\u95eb\u521b\u4e1a\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u5728\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u8f6c\u8fd0\u4f53\uff08NET\uff09\u8fd9\u4e00\u4e34\u5e8a\u76f8\u5173\u9776\u70b9\u4e0a\u5f00\u5c55\u4e86\u7cfb\u5217\u751f\u7269\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/p>\n

NET\u662f2024\u5e74\u624d\u521a\u89e3\u6790\u51fa\u7ed3\u6784\u7684\u9776\u70b9\uff0c\u662f\u6291\u90c1\u75c7\u3001\u6ce8\u610f\u7f3a\u9677\u591a\u52a8\u75c7\u4ee5\u53ca\u75bc\u75db\u7b49\u75be\u75c5\u7684\u91cd\u8981\u9776\u70b9\uff0c\u76ee\u524d\u867d\u7136\u6709\u591a\u6b3e\u6291\u5236\u5242\u5df2\u7ecf\u4e0a\u5e02\uff0c\u4f46\u662f\u5728\u9009\u62e9\u6027\u7b49\u65b9\u9762\u4ecd\u7136\u6709\u5de8\u5927\u7684\u4f18\u5316\u7a7a\u95f4\u3002<\/p>\n

\u56e2\u961f\u4f7f\u7528DrugCLIP\u6a21\u578b\u4ece160\u4e07\u4e2a\u5019\u9009\u5206\u5b50\u4e2d\u7b5b\u9009\u51fa\u7ea6100\u4e2a\u9ad8\u8bc4\u5206\u5206\u5b50\uff0c\u540c\u4f4d\u7d20\u914d\u4f53\u8f6c\u8fd0\u5b9e\u9a8c\u68c0\u6d4b\u663e\u793a\u5176\u4e2d15%\u4e3a\u6709\u6548\u6291\u5236\u5242\uff0c\u5176\u4e2d12\u4e2a\u5206\u5b50\u7ed3\u5408\u80fd\u529b\u4f18\u4e8e\u73b0\u6709\u6297\u6291\u90c1\u836f\u7269\u5b89\u975e\u4ed6\u916e\u3002<\/p>\n

\u76f8\u5173\u590d\u5408\u7269\u7ed3\u6784\u5df2\u901a\u8fc7\u51b7\u51bb\u7535\u955c\u89e3\u6790\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86DrugCLIP\u7b5b\u9009\u7ed3\u679c\u7684\u751f\u7269\u5b66\u53ef\u4fe1\u5ea6\u3002<\/p>\n

DrugCLIP\u8fd8\u652f\u6301\u5bf9AlphaFold\u9884\u6d4b\u7684\u86cb\u767d\u7ed3\u6784\u548capo\uff08\u65e0\u914d\u4f53\uff09\u72b6\u6001\u4e0b\u7684\u86cb\u767d\u53e3\u888b\u8fdb\u884c\u7b5b\u9009\u3002<\/p>\n

\u56e2\u961f\u548c\u6e05\u534e\u5927\u5b66\u5218\u78ca\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u9488\u5bf9E3\u6cdb\u7d20\u8fde\u63a5\u9176TRIP12\uff08thyroid hormone receptor interactor 12\uff09\u7684HECT\u7ed3\u6784\u57df\u8fdb\u884c\u4e86\u865a\u62df\u7b5b\u9009\u4e0e\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/p>\n

\u5f53\u65f6\u8fd9\u662f\u4e00\u4e2a\u65e2\u6ca1\u6709\u5b9e\u9a8c\u7ed3\u6784\u3001\u4e5f\u6ca1\u6709\u4efb\u4f55\u5df2\u77e5\u6291\u5236\u5242\u7684\u86cb\u767d\uff0c\u4e0e\u764c\u75c7\u548c\u5e15\u91d1\u68ee\u75c5\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n

\u56e2\u961f\u4f7f\u7528DrugCLIP\u6a21\u578b\u5bf9AlphaFold2\u9884\u6d4b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u7b5b\u9009\uff0c\u4ece160\u4e07\u4e2a\u5019\u9009\u5206\u5b50\u4e2d\u9ad8\u901a\u91cf\u7b5b\u9009\u51fa\u7ea650\u4e2a\u9ad8\u8bc4\u5206\u5206\u5b50\u3002<\/p>\n

SPR\u5b9e\u9a8c\u8bc1\u5b9e\u5176\u4e2d10\u4e2a\u5206\u5b50\u4e0eTRIP12\u6709\u7ed3\u5408\u80fd\u529b\uff0c\u4e24\u4e2a\u4eb2\u548c\u529b\u8f83\u9ad8\u7684\u5206\u5b50\u4e5f\u5bf9TRIP12\u7684\u6cdb\u7d20\u8fde\u63a5\u9176\u6d3b\u6027\u6709\u4e00\u5b9a\u7684\u6291\u5236\u6d3b\u6027\u3002<\/p>\n

\u5728\u5355\u9776\u70b9\u9a8c\u8bc1\u4e4b\u5916\uff0cDrugCLIP\u8fd8\u5b8c\u6210\u4e86\u4e00\u6b21\u524d\u6240\u672a\u6709\u7684\u5168\u5c40\u7b5b\u9009\u3002<\/p>\n

\u7814\u7a76\u56e2\u961f\u9996\u6b21\u5b8c\u6210\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u89c4\u6a21\u7684\u865a\u62df\u7b5b\u9009\u9879\u76ee\uff0c\u8986\u76d6\u7ea61\u4e07\u4e2a\u86cb\u767d\u9776\u70b9\u30012\u4e07\u4e2a\u7ed3\u5408\u53e3\u888b\uff0c\u5206\u6790\u8d85\u8fc75\u4ebf\u4e2a\u5c0f\u5206\u5b50\uff0c\u5bcc\u96c6\u51fa200\u4e07\u4f59\u4e2a\u9ad8\u6f5c\u529b\u6d3b\u6027\u5206\u5b50\u3002<\/p>\n

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DrugCLIP\u7531\u6e05\u534e\u5927\u5b66\u667a\u80fd\u4ea7\u4e1a\u7814\u7a76\u9662\uff08AIR\uff09\u535a\u58eb\u540e\u8d3e\u5bc5\u541b\u3001\u8ba1\u7b97\u673a\u7cfb\u535a\u58eb\u751f\u9ad8\u535a\u6587\u3001\u751f\u547d\u5b66\u9662\u535a\u58eb\u540e\u8c2d\u4f73\u946b\u3001\u5316\u5b66\u7cfb\u535a\u58eb\u540e\u90d1\u6d4e\u9752\u4ee5\u53ca\u667a\u80fd\u4ea7\u4e1a\u7814\u7a76\u9662\uff08AIR\uff09\u535a\u58eb\u540e\u6d2a\u946b\u4e3a\u5171\u540c\u4e00\u4f5c\u3002<\/p>\n

\u901a\u8baf\u4f5c\u8005\u4e3a\u667a\u80fd\u4ea7\u4e1a\u7814\u7a76\u9662\uff08AIR\uff09\u5170\u8273\u8273\u6559\u6388\uff0c\u751f\u547d\u5b66\u9662\u5f20\u4f1f\u526f\u6559\u6388\u3001\u95eb\u521b\u4e1a\u526f\u6559\u6388\u4ee5\u53ca\u5316\u5b66\u7cfb\u5218\u78ca\u6559\u6388\u3002<\/p>\n

\u8be5\u9879\u76ee\u5f97\u5230\u4e86\u56fd\u5bb6\u79d1\u6280\u90e8\u91cd\u70b9\u7814\u53d1\u9879\u76ee\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u9879\u76ee\u3001\u65b0\u57fa\u77f3\u7814\u7a76\u57fa\u91d1\u7b49\u9879\u76ee\u7684\u652f\u6301\uff0c\u540c\u65f6\u8fd8\u6709\u6e05\u534e\u5927\u5b66\u65e0\u9521\u5e94\u7528\u6280\u672f\u7814\u7a76\u9662\u667a\u80fd\u4ea7\u4e1a\u521b\u65b0\u4e2d\u5fc3\u3001\u5317\u4eac\u667a\u6e90\u4eba\u5de5\u667a\u80fd\u7814\u7a76\u9662\u4e0e\u5317\u4eac\u7ed3\u6784\u9ad8\u7cbe\u5c16\u4e2d\u5fc3\u7b49\u673a\u6784\u7684\u652f\u6301\u3002<\/p>\n

\u672a\u6765\uff0cDrugCLIP\u5c06\u4e0e\u79d1\u7814\u4ea7\u4e1a\u751f\u6001\u5408\u4f5c\u4f19\u4f34\u6df1\u5ea6\u5408\u4f5c\uff0c\u5728\u6297\u764c\u3001\u4f20\u67d3\u75c5\u3001\u7f55\u89c1\u75c5\u7b49\u65b9\u5411\u52a0\u901f\u65b0\u9776\u70b9\u4e0eFirst-in-class\u836f\u7269\u7684\u53d1\u73b0\u3002<\/p>\n

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\n

\u7248\u6743\u58f0\u660e\uff1a<\/strong><\/p>\n

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\u4e00\u5929\u7b5b\u9009\u5341\u4e07\u4ebf\u6b21\uff0c\u4e2d\u56fdAI\u627e\u836f\u53c8\u6709\u65b0\u7a81\u7834\uff01<\/p>\n

\u6e05\u534e\u5927\u5b66\u667a\u80fd\u4ea7\u4e1a\u7814\u7a76\u9662\uff08AIR\uff09\u8054\u5408\u6e05\u534e\u5927\u5b66\u751f\u547d\u5b66\u9662\u3001\u6e05\u534e\u5927\u5b66\u5316\u5b66\u7cfb\u5728Science\u4e0a\u53d1\u8868\u8bba\u6587\uff1a\u300a\u6df1\u5ea6\u5bf9\u6bd4\u5b66\u4e60\u5b9e\u73b0\u57fa\u56e0\u7ec4\u7ea7\u522b\u836f\u7269\u865a\u62df\u7b5b\u9009\u300b\u3002<\/p>\n

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DrugCLIP\u80fd\u8ba9AI\u4ece\u6d77\u91cf\u5316\u5b66\u5206\u5b50\u91cc\uff0c\u8fc5\u901f\u7b5b\u51fa\u90a3\u4e9b\u6700\u6709\u5e0c\u671b\u548c\u75be\u75c5\u76f8\u5173\u86cb\u767d\u7ed3\u5408\u7684\u201c\u5019\u9009\u836f\u7269\u5206\u5b50\u201d\u3002<\/p>\n

24\u5c0f\u65f6\u5185\uff0cDrugCLIP\u80fd\u5b8c\u62101<\/p>\n","protected":false},"author":1,"featured_media":793,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[244],"class_list":["post-797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-xwzx","tag-ai"],"_links":{"self":[{"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/posts\/797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/comments?post=797"}],"version-history":[{"count":0,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/posts\/797\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/media\/793"}],"wp:attachment":[{"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/media?parent=797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/categories?post=797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/1ow.top\/index.php\/wp-json\/wp\/v2\/tags?post=797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}